Dr. Rose is the Director of the Duke Center for Smoking Cessation and a Professor in the Department of Psychiatry and Behavioral Sciences at Duke University Medical Center. He began work in the area of tobacco addiction research as a NIMH Postdoctoral fellow at the University of California at Los Angeles. A main focus of his research program has been the elucidation of the role of sensorimotor cues and the CNS effects of nicotine in reinforcing cigarette smoking behavior. He is co-inventor of the nicotine skin patch and other treatments for smoking cessation. His primary research goals are to elucidate the biological mechanisms underlying tobacco addiction and to promote the development of more effective treatments. Under his direction, the Center is focusing on personalized and adaptive treatment approaches, in which genomic and phenotypic markers are used to tailor treatment to the individual smoker, and the initial treatment can be modified based on early indicators of therapeutic outcome.
Other Principal Investigators:
Edward D. Levin, PhD
Director of Preclinical Trials
Nicotine addiction, cognitive function, learning,
memory, attention deficit disorder, schizophrenia,
toxicology, effects of prenatal nicotine exposure
James Davis, MD
Medical Director
Smoking cessation clinical algorithm evaluation; mindfulness research
Alexey G. Mukhin, MD, PhD
Principal Investigator
Pharmacokinetics of nicotine; PET imaging of the human brain
Raju Murugesan, PhD
Principal Investigator
Analytical chemistry and mass spectrometry; Interest in developing novel nicotine replacement therapy for smoking cessation and tobacco addiction
H. Scott Swartzwelder, PhD
Principal Investigator
Effects of drug abuse on the brain and behavior,
alcohol effects on learning and memory, underage
drinking
Wilkie A. Wilson, PhD
Principal Investigator
How drugs interact with the central nervous system; interests in how the brain acquires and stores information and educational support
Yantao Zuo, PhD
Principal Investigator
Interested in neurobiological and psychological mechanisms and factors of nicotine addiction and tobacco dependence. Focused on using neuroimaging approaches (EEG, fMRI, and PET) to investigate the brain mechanisms underlying addictive effects of nicotine and nicotine withdrawal; understanding individual differences (sex, genetic makeup, neurobiological markers, and personality traits) in affective and craving processes during smoking abstinence and cessation