Principal Investigators

Jed E. Rose, PhD, Director



Dr. Rose is the Director of the Duke Center for Smoking Cessation and a Professor in the Department of Psychiatry and Behavioral Sciences at Duke University Medical Center. He began work in the area of tobacco addiction research as a NIMH Postdoctoral fellow at the University of California at Los Angeles. A main focus of his research program has been the elucidation of the role of sensorimotor cues and the CNS effects of nicotine in reinforcing cigarette smoking behavior. He is co-inventor of the nicotine skin patch and other treatments for smoking cessation. His primary research goals are to elucidate the biological mechanisms underlying tobacco addiction and to promote the development of more effective treatments. Under his direction, the Center is focusing on personalized and adaptive treatment approaches, in which genomic and phenotypic markers are used to tailor treatment to the individual smoker, and the initial treatment can be modified based on early indicators of therapeutic outcome.


Other Principal Investigators:


Edward D. Levin, PhD
Director of Preclinical Trials

Nicotine addiction, cognitive function, learning,
memory, attention deficit disorder, schizophrenia,
toxicology, effects of prenatal nicotine exposure


James Davis, MD
Medical Director

Smoking cessation clinical algorithm evaluation; mindfulness research


Santanu Datta, PhD
Principal Investigator

Intervention and implementation cost analyses, cost-effectiveness analysis, decision analytic modeling, budget impact analysis, and utility/preference measurement


Alexey G. Mukhin, MD, PhD
Principal Investigator

Pharmacokinetics of nicotine; PET imaging of the human brain


Raju Murugesan, PhD
Principal Investigator

Analytical chemistry and mass spectrometry; Interest in developing novel nicotine replacement therapy for smoking cessation and tobacco addiction


H. Scott Swartzwelder, PhD
Principal Investigator

Effects of drug abuse on the brain and behavior,
alcohol effects on learning and memory, underage


Wilkie A. Wilson, PhD
Principal Investigator

How drugs interact with the central nervous system; interests in how the brain acquires and stores information and educational support


Yantao Zuo, PhD
Principal Investigator

Interested in neurobiological and psychological mechanisms and factors of nicotine addiction and tobacco dependence. Focused on using neuroimaging approaches (EEG, fMRI, and PET) to investigate the brain mechanisms underlying addictive effects of nicotine and nicotine withdrawal; understanding individual differences (sex, genetic makeup, neurobiological markers, and personality traits) in affective and craving processes during smoking abstinence and cessation