Listed below are publications that our Center’s investigators have authored since 2010.




Levin ED, Hall BJ, Chattopadhyay A, Slade S, Wells C, Rezvani AH, Rose JE.  Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats, Psychopharmacology, 2016 June 18. doi: 10.1007/s00213-016-4347-1 [Epub ahead of prinit]  PMID: 27318988


Swartzwelder, H.S., Risher, M-L., Miller, K.M., Colbran, R.J., Winder, D.G. and Wills, T.A. Changes in the adult GluN2B associated proteome following adolescent intermittent ethanol exposure. PLoS One (in press), 2016.


Macaulay LJ, M Chernick, A Chen, DE Hinton, JM. Bailey, SW Kullman, ED Levin and HM Stapleton. Exposure to PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. Environmental Toxicology and Chemistry, in press, 2016.


Levin ED, BJ Hall, A Chattopadhyay, S Slade, C Wells, AH Rezvani and JE Rose. Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade. Psychopharmacology, in press, 2016


Rezvani AH, ED Levin, C Wells, M Morrison and L Lumeng. Different lines of rats selectively-bred for high alcohol drinking show disparate Preferences for nicotine self-administration. Journal of Drug and Alcohol Research, Vol. 5, Article ID 235972, 9 pages, doi:10.4303/jdar/235972, 2016; PMCID: In process.


Hall BJ, M Cauley, D Burke, A Kiany, TA Slotkin and ED Levin. Cognitive and behavioral impairments evoked by low-level exposure to tobacco smoke constituents: Comparison with nicotine alone. Toxicological Sciences, 15:236-244, 2016; PMCID: In process.


Bao X, Vi Chandramohan, R Reynolds, J Norton, WC Wetsel, RM Rodriguiz, RE McLendon, ED Levin, NA Petry, MR Zalutsky, BK Burnett, CT Kuan, IH Pastan, and DD Bigner. A preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats. Investigational New Drugs, 34:149-158, 2016; PMCID: In process.


Briggs SA, C Wells, S Slade, P Jaskowski, M Morrison, BJ Hall, AH Rezvani, JE Rose and ED Levin. Dextromethorphan interactions with serotonergic and histaminergic treatments to reduce nicotine self-administration, Pharmacology, Biochemistry and Behavior, 142:1-7, 2016; PMC4749472.


Brown DR, JM Bailey, AN Oliveri, ED Levin and RT Di Giulio. Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. Neurotoxicology and Teratology, 53:55-63, 2016; PMCID: 4803068.


Levin ED. Crumbling infrastructure and learning impairment: A call to responsibility. Environmental Health Perspectives, 124:A79, 2016




Briggs SA, Hall BJ, Wells C, Slade S, Jaskowski P, Morrison M, Rezvani AH, Rose JE, Levin ED. Dextromethorphan interactions with histaminergic and serotonergic treatments to reduce nicotine self-administration in rats, Pharmacology Biochemistry and Behavior, 2015 Dec 15;142:1-7. doi: 10.1016/j.pbb.2015.12.004. [Epub ahead of print]  PMID: 26704812


Levin ED, AV Kalueff and RT Gerlai. Perspectives on zebrafish neurobehavioral pharmacology. Pharmacology, Biochemistry and Behavior. 139: 93, 2015.

Levin ED, Wells C, Johnson JE, Rezvani AH, Bymaster FP, Rose JE.  Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats.  European Journal of Pharmacology,  2015 June 15. doi: 10.1016/j.ejphar.2015.06.041. [Epub ahead of print]  PMID: 26101069


Rose JE, Behm FM. Response to Gorelick. American Journal of Psychiatry, 2015 Apr 172(4): 395.  doi: 10.1176/appi.ajp.2015.14111429r.  PMID: 25827038.


McClernon FJ, Froeliger B, Rose JE, Kozink RV, Addicott MA, Sweitzer MM, Westman EC, Van Wert DM.  The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function.  Addiction Biology,  2015 Apr 22. doi: 10.1111/adb.12253. [Epub ahead of print] PMID: 25904425;  PMCID: PMC4618271


Addicott MA, Sweitzer MM, Froeliger B, Rose JE, McClernon FJ. Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes Neuropsychopharmacology, 2015 Apr 21. doi: 10.1038/npp.2015.114. [Epub ahead of print]  PMID: 25895453; PMCID: PMC4569957


Hall BJ, Slade S, Wells C, Rose JE, Levin ED. Bupropion-varenicline interactions and nicotine self-administration behavior in rats Pharmacology Biochemistry and Behavior, 2015 Mar;130:84-9. doi: 10.1016/j.pbb.2015.01.009. Epub 2015 Jan 20.  PMID: 25616031; PMCID: PMC4331343


Hall BJ, Wells C, Allenby C, Lin MY, Hao I, Marshall L, Rose JE, Levin ED. Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats. Pharmacology, Biochemistry and Behavior 120:103–108, 2015.  PMID: 24560911; PMCID: PMC4000725


Walton KM, Abrams DB, Bailey WC, Clark D, Connolly GN, Djordjevic MV, Eissenberg TE, Fiore MC, Goniewicz ML, Haverkos L, Hecht SS, Henningfield JE, Hughes JR, Oncken CA, Postow L, Rose JE, Wanke KL, Yang L, Hatsukami DK. NIH electronic cigarette workshop: Developing a research agenda. Nicotine & Tobacco Research,  17(2):259-269, 2015. doi: 10.1093/ntr/ntu 214. First published online: October 21, 2014.  PMID: 25335949; PMCID: PMC4311173


Bailey JM, AN Oliveri, N Karbhari, RA Brooks, AJ De La Rocha, S Janardhan and ED Levin. Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. NeuroToxicology, 52:23-33, 2015; PMCID: PMC4753107


Oliveri AN, JM Bailey and ED Levin. Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish.  Neurotoxicology and Teratology, 52:220-227, 2015; PMC4769864.


Bailey JM and ED Levin. Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures. Neurotoxicology and Teratology, 52:210-219, 2015; PMC4679535.


Macaulay LJ, JM Bailey, ED Levin and HM Stapleton. Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. Neurotoxicology and Teratology, 52:119-126, 2015; PMC4644107.


Levin ED. Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery. Neurotoxicology and Teratology, 52:88-92, 2015; PMC4656139.


Massarsky A, N Jayasundara, Jordan M Bailey, AN Oliveri, ED Levin, G. Prasad, RT Di Giulio. Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. Neurotoxicology and Teratology, 51:77-88, 2015; PMC4821439.


Bailey JM, AN Oliveri and ED Levin. Pharmacological analyses of learning and memory in zebrafish (Danio rerio). Pharmacology, Biochemistry and Behavior, 139:103-111, 2015; PMC4573775.


Hall BJ, S Slade, C Allenby, ED Levin. Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. Neuropharmacology, 99:689-695, 2015; PMC4575603.


Crosby, EB, JM, Bailey, AN Oliveri and ED Levin. Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. Neurotoxicology and Teratology, 49:81-90, 2015; PMCID: PMC4458463.


Slotkin TA, S Skavicus, J Card, A Stadler, ED Levin and FJ Seidler. Developmental neurotoxicity of tobacco smoke extract toward cholinergic and serotonergic systems: More than just nicotine. Toxicological Sciences, 147:178-189, 2015; PMCID: PMC4679867.


Larrauri JA, DA Burke, BJ Hall and ED Levin. Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats,  Psychopharmacology, 232:3009-3017, 2015; PMCID: PMC4515155.


Slotkin TA, S Skavicus, J Card, ED Levin and FJ Seidler Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. Toxicology, 333:63-75, 2015; PMCID: PMC4466202


Bailey JM, AN Oliveri, C Zhang, JM Fraizer, S Mackinnon, GJ Cole and ED Levin. Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish. Neurotoxicology and Teratology, 48:1-8, 2015; PMCID: PMC436320.


Slotkin TA, S Skavicus, ED Levin and FJ Seidler. Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function, Brain Research Bulletin, 111:84-96, 2015, PMCID: PMC4324014.


Levin ED, BJ Hall and AH Rezvani. Heterogeneity across brain regions and neurotransmitter interactions with nicotinic effects on memory function. In: The Neurobiology and Genetics of Nicotine and Tobacco, D Balfour and M Munafo (Eds.), Current Topics in Behavioral Neurosciences, Springer, Inc, Heidelberg, Germany, 87-101, 2015; PMID: 25655888; PMCID: In process.


Davis JM, Manley BA, Goldberg BA, Stankevitz KA, Smith SS, Mindfulness training for smokers via web-based video instruction with phone support: a prospective observational study.  BMC Complementary and Alternative Medicine March 29, 2015, NCT01679236, DOI 10.1186/s12906-015-0618-3.


Risher, M.L., Sexton, H.G., Risher, W.C., Wilson, W.A., Fleming, R.L., Madison, R.D., Eroglu, C. and Swartzwelder, H.S. Adolescent intermittent alcohol exposure: dysregulation of astrocyte 25 synaptogenic factors, and decreased neuron density in the adult hippocampus. Alcoholism: Clin. Exp. Res. 39(12): 2403-2413, 2015


Swartzwelder, H.S., Acheson, S.K., Miller, K.M., Sexton, H.G., Liu, W., Crews, F.T. and Risher M-L. Adolescent intermittent alcohol exposure: Deficits in object recognition memory and forebrain cholinergic markers. PloS One 10.11: e0140042, 2015.


Risher, M.L., Fleming, R.L., Risher, W.C., Miller, K.M., Klein, R.C., Wills, T.A., Acheson, S.K., Moore, S.D., Wilson, W.A., Eroglu, C. and Swartzwelder, H.S. Adolescent intermittent alcohol exposure: Persistence of structural and functional hippocampal abnormalities into adulthood. Alcoholism: Clin. Exp. Res. 39 (6): 989-997, 2015.





Zuo Y, Mukhin AG, Garg S, Nazih R, Behm FM, Garg PK, Rose JE. Sex-specific effects of cigarette mentholation on brain nicotine accumulation and smoking behavior. Neuropsychopharmacology, 2014 Sep 30. doi: 10.1038/npp.2014.263. [Epub ahead of print]  PMID: 25267342; PMCID: PMC4330502


Cousins V, Rose JE, Levin Ed. Nicotine IV self-administration in rats using the consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs. Progress in Neuropsychopharmacology & Biological Psychiatry, 54:200-5. doi: 10.1016/j.pnpbp.2014.06.004. Epub Jun 20, 2014.  PMID: 24953434; PMCID: PMC4135026


Dehkordi O, Rose J, Asadi S, Manaye K, Millis R, Trouth A. Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system. Journal of Neuroscience Research, DOI: 10.1002/jnr.23477, 2014.  PMID: 25223294; PMCID: PMC4270827


Rose JE, Behm FM. Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. American Journal of Psychiatry, 2014 Jun 17. doi: 10.1176/appi.ajp.2014.13050595. [Epub ahead of print] PMID: 24934962; PMCID: PMC4557205


Brody AL, Mukhin AG, Mamoun MS, Luu T, Neary M, Liang L, Shieh J, Sugar CA, Rose JE, Mandelkern M. Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment. JAMA Psychiatry 2014 Jul 1;71(7):797-805. Published online May 21, 2014. doi:10.1001/jamapsychiatry.2014.138.  PMID: 24850280


Addicott M, Froeliger B, Kozink R, Wert DV, Westman E, Rose JE, McClernon F. Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. Neuropsychopharmacology, 39(12):2750-9. doi: 10.1038/npp.2014.108. Epub May 13, 2014.  PMID: 24820539; PMCID: PMC4200485


Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny JP, Tyndale RF, David SP, Stein EA, Uhl GR, Conti DV, Green C, and Amur S. Biomarkers for smoking cessation. Clinical Pharmacology and Therapeutics, 93(6):526-538, 2014.  PMID: 23588313; PMCID: PMC3772534


Uhl GR, Walther D, Musci R, Fisher C, Anthony JC, Storr CL, Behm FM, Eaton WW, Ialongo N and Rose JE. Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. Molecular Psychiatry, 19, 50–54, 2014.  advance online publication, 6 November 2012; doi:10.1038/mp.2012.155      PMID: 23128154; PMCID: PMC3922203

Rezvani AH and ED Levin. Lorcaserin, a selective 5-HT2c receptor agonist, decreases alcohol intake in female alcohol preferring rats. Pharmacology, Biochemical and Behavior, 125:1-8, 2014. PMID: 25109272; PMCID: In process


Rezvani AH, ED Levin, MP Arolfo, C Wells, M Graupe, and I Diamond. Inhibition of aldehyde dehydrogenase-2 (ALDH-2) suppresses nicotine self-administration in rats. Journal of Drug and Alcohol Research, Vol. 4, 6 pages, ID235940, 2015; PMCID: In process.


Levin ED, I Hao, D Burke, M Cauley, BJ Hall and AH Rezvani. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. Journal of Psychopharmacology, 28:915-922, 2014. PMCID: PMC4305443


Skefos J, M Ghulam, A Mahendra, G Patel, J Larrauri, E Kholdebarin, ED Levin and M Bauman. Histamine and acetylcholine receptor involvement in sensorimotor gating: An autoradiography study. F1000 Research, 3:136, 2014; PMCID: In process.


Rezvani AH and ED Levin. Effects of anabasine, a tobacco smoke constituent, on alcohol consumption in female alcohol preferring (P) rats. The Journal of Drug and Alcohol Research, 3:1-6, Article ID 235858, 2014; PMCID: In process.


Rezvani AH and ED Levin. Assessment of pregnenolone effects on alcohol intake in male alcohol preferring (P) rats. European Journal of Pharmacology, 740:53-57, 2014, PMID: 25016089; PMCID: In process.


Slotkin TA, J Card, A Stadler, ED Levin and FJ Seidler. Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene. Neurotoxicology and Teratology, 43:19-24, 2014, PMCID: PMC4043937.


Burke DA, P Heshmati, E Kholdebarin and ED Levin. Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats. European Journal of Pharmacology, 741:132-139, 2014, PMCID: PMC4184962


Levin ED, M Cauley, J Johnson, EM Cooper, HM Stapleton, PL Ferguson, FJ Seidler and TA Slotkin. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos:  Significance for maternal stress and preterm labor. Neurotoxicology and Teratology, 41:35-42, 2014; PMCID: PMC3943881


Larrauri JA, LD Kelley, MR Jenkins, EC Westman, NA Schmajuk, MZ Rosenthal, ED Levin. Meclizine enhancement of sensorimotor gating in healthy male subjects with high startle responses and low prepulse inhibition. Neuropsychopharmacology, 39:651-659, 2014, PMCID: PMC3895242.


Levin ED. Developmental toxicology and children’s environmental health. In: Textbook of Children’s Environmental Health. PJ Landrigan and RA Etzel (eds.), Oxford University Press, New York, 83-88, 2014.


Levin ED. Nicotinic attention deficit/hyperactivity disorder treatment. Biological Psychiatry. 75:174, 2014.


Goldberg SB, Manley AR, Smith SS, Greeson JM, Russell E, MS,7  Uum SV, Gideon Koren G, Davis, JM,  Hair Cortisol as a Biomarker of Stress in Mindfulness Training for Smokers,  Journal of Alternative and Complementary Medicine, Volume 00, Number 0, 2014, pp. 1–5 DOI: 10.1089/acm.2014.0080 PMID 24963659 PMCID: PMC4129663.


Davis, J.M., Manley A.R., Goldberg SB, Smith S.S., Jorenby D.E.   Randomized trial comparing mindfulness training for smokers to a matched control J Substance Abuse Treatment, Sept 14, 2014, NCT01299909 NIHMS 591996. PMID 24957302  PMCID: PMC4121076


Goldberg SB, Del Rey AC, Hoyt WT, Davis JM.  The secret ingredient in mindfulness interventions?  A case for practice quality over quantity.  Journal of Counseling Psychology July, 2014: 61(3): 491-7 PMID 25019551.


Davis JM, Goldberg SB, Anderson MC, Manley AR, Smith SS, Baker TB Randomized trial on mindfulness training for smokers targeting a disadvantaged population.  J Subst Use Misuse. 2014 Apr:49(5):571-85 PMCID:PMC3955013.


Davis, J.M., Sandgren, A.J., Manley, A.R., & Smith, S.S., Optimizing Clinical Trial Enrollment Through “Goal Programing” Applied Clinical Trials.  March 12, 2014; NIHMSID: 587276


Spear, L.P. and Swartzwelder, H.S. Adolescent alcohol exposure and persistence of adolescenttypical phenotypes into adulthood: a mini-review. Neuroscience and Biobehavioral Reviews 45: 1–8, 2014


Centanni, S.W., Teppen, T., Risher, M-L., Fleming, R.L., Moss, J.L., Acheson, S.K., Mulholland, P.J., Pandey, S.C., Chandler, L.J. and Swartzwelder, H.S. Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus. Alcoholism: Clin. Exp. Res. 38(11): 2800-2808, 2014


Klein, R., Saini, S., Risher, M-L., Acheson, S., Fleming, R., Sexton, H., Swartzwelder, H.S. and Moore, S.D. Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. PLoS One 9 (4): e94071 1-9, 2014.


Swartzwelder, H.S., Hogan, A., Risher, M-L., Swartzwelder, R.A., Wilson, W.A. and Acheson, S.K. Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats. Alcohol 48(4): 353-360, 2014


Kuhn, C., Swartzwelder, H.S., and Wilson, W.A. Buzzed: The Straight Facts About the Most Used and Abused Drugs from Alcohol to Ecstasy. W.W. Norton & Co., 1998.

Second Edition Published, 2003.

Third Edition Published, 2008.

Fourth Edition Published, 2014.


Italian, 2009

Spanish, 2011

Portuguese, 2011

Special Spanish Edition, 2012

Chinese, 2014





Rose JE and Behm FM. Adapting quit-smoking treatment based on initial response to pre-cessation nicotine patch. American Journal of Psychiatry 170(8):860-7. doi: 10.1176/appi.ajp.2013.12070919, 2013. PMID: 23640009; PMCID: PMC4562286


Levin ED, HG Sexton, K Gordon, CJ Gordon, Y Xiao, KJ Kellar, VM Yenugonda, Y Liu, MP White, M Paige, ML Brown and AH Rezvani. Effects of the sazetidine-A family of compounds on the body temperature in wildtype, nicotinic receptor b2-/- and a7-/- mice. European Journal of Pharmacology, 718:167-172, 2013, PMCID: PMC3844546


Kutlu MG, D Burke, S Slade, BJ Hall, JE Rose and ED Levin. Role of insular cortex D1 and D2 dopamine receptors in nicotine self-administration in rats. Behavioural Brain Research, 256:273-278, 2013; PMCID: PMC3874126.


Levin ED. Complex relationships of nicotinic receptor actions and cognitive functions. Biochemical Pharmacology, 86:1145-1152, 2013, PMCID: PMC3797209.


Yenugonda VM, Y Xiao, ED Levin, AH Rezvani, T Tran, N Al-Muhtasib, C Wells, S Slade, JE Johnson, S Dakshanamurthy, HS Kong, Y Tomita, Y Liu, MA Paige, KJ Kellar and ML Brown. Design, synthesis and discovery of picomolar selective a4b2 nicotinic acetylcholine receptor inhibitors. Journal of Medicinal Chemistry, 56:8404-8421, 2013. PMID: 24047231, PMCID: in process.


Bailey JM, A Oliveri and ED Levin. Zebrafish model systems for developmental neurobehavioral toxicology. Birth Defects Research (Part C), 99:14-23, 2013, PMCID: PMC4000730.


Rezvani AH, HG Sexton, J Johnson, C Wells, K Gordon and ED Levin. Effects of caffeine on  alcohol consumption and nicotine self-administration in rats, Alcoholism: Clinical  and Experimental Research, 37:1609-1617, 2013, PMCID: PMC3775986


Risher, ML, RL Fleming, N Boutros, S Semenova, WA Wilson, ED Levin, A Markou, HS Swartzwelder and SK Acheson. Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: Radial-arm maze performance and operant reinforced responding. PloS-One, 8(5):e62940, 2013, PMCID: PMC3652810


Liu Y, J Richardson, T Tran, N Al-Muhtasib, T Xie, VM Yenugonda, HG Sexton, AH Rezvani, ED Levin, N Sahibzada, KJ Kellar, M. Brown, Y Xiao and M Paige. Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nAChRs ligands that reduces alcohol intake in rats. Journal of Medicinal Chemistry, 56:3000-3011, 2013, PMCID: PMC3809750


Coppola A, BR Wenner, RD Stevens, O Ilkayeva, M Maggioni, TA Slotkin, ED Levin, CB Newgard. Branched chain amino acids alter neurobehavioral function in rats. American Journal of Physiology – Endocrinology and Metabolism, 304(4):E405-413, 2013, PMCID: PMC3566503.


Levin ED, M Cauley and AH Rezvani. Improvement of attentional function with antagonism of nicotinic receptors in female rats. European Journal of Pharmacology, 702:269-274, 2013, PMCID: PMC3624620


Behl M, D Rao, K Aagaard, TL Davidson, ED Levin, TA Slotkin, S Srinivasan, D Wallinga, MF White, VR Walker, KA Thayer and AC Holloway. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: A National Toxicology Program workshop review. Environmental Health Perspectives, 121:170-180, 2013, PMCID: PMC3569686.


Acheson, S.K., Bearson, C., Risher, M-L., Abdelwahab, S.H., Wilson, W.A. and Swartzwelder,H.S. Effects of acute or chronic ethanol exposure during adolescence on behavioral inhibition and efficiency in a modified water maze task. PLoS One 8 (10): e77768 1-15, 2013


Kuhn, C., Wilson, W.A. and Swartzwelder, H.S. Enduring effects of adolescent drug exposure. Biological Psychiatry 74(7): 480-481, 2013


Li, Q., Fleming, R.L., Acheson, S.K., Madison, R.D., Moore, S.D., Risher, M-L., Wilson, W.A. and Swartzwelder, H.S. Long-term modulation of A-type K+ conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood. Alcoholism: Clin. Exp. Res. 37(12): 2074-85, 2013


Fleming, R.L., Li, Q., Risher, M-L, Sexton, H., Moore, S., Wilson, W.A., Acheson, S.K. and Swartzwelder, H.S. Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells. Alcoholism: Clin. Exp. Res. 37(7): 1154-60, 2013


Davis, J.M., Mills, D.M., Stankevitz, K.A., Manley, A.R., Majeskie, M.R., & Smith, S.S. Pilot study on mindfulness training for smokers in young adult binge drinkers. Journal of Complementary and Alternative Medicine, September 3, 2013; PMID: 24006963, NCT01679236.


Goldberg S, Davis JM, Hoyt WT. The role of therapeutic alliance in mindfulness interventions: therapeutic alliance in Mindfulness Training for Smokers. J Clin Psychol. 2013 Sep;69(9):936-50. PMCID: PMC3869569.


Davis, J.M., Anderson, M.C., Stankevitz, K.A., & Manley, A.R., Providing premedical students with quality clinical and research experience – the tobacco scholars program, Wisconsin Medical Journal, October 2013.





Dehkordi O, Rose JE, Fatemi M, Allard JS, Balan KV, Young JK, Fatima S, Millis RM, Jayam-Trouth A. Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. Brain Research,1475:1-10, 2012. doi: 10.1016/j.brainres.2012.07.038. Epub 2012 Jul 24.  PMID: 22836012


Rose JE, Dehkordi O, Fatemi M, Raghupathi R, Mills RM and Jayam-Trouth A. Neuroanatomical evidence for a putative autocrine/paracrine signaling system involving nicotinic acetylcholine receptors, purinergic receptors, and nitric oxide synthase in the airwaysJournal of Neuroscience Research, 90(4): 849-59, April 2012.  PMID: 22420037


Rezvani, AH, M Cauley, Y Xiao, KJ Kellar and ED Levin. Effects of chronic sazetidine-A, a selective β2* nicotinic receptor desensitizing agent on pharmacologically-induced impaired sustained attention in rats. Psychopharmacology, 222:269-276, 2012, PMID: 23100170 PMCID: in process.


Hussmann GP, JR Turner, E Lomazzo, V Cousins, Y Xiao, RP Yasuda, BB Wolfe, DC Perry, JA Blendy, AH Rezvani, ED Levin and KJ Kellar. Chronic sazetidine-A at behaviorally active doses does not increase nicotine cholinergic receptors in rodent brain. Journal of Pharmacology and Experimental Therapeutics, 343:441-450, 2012, PMCID: PMC3477215.


Swartzwelder NA, ML Risher, SH Abdelwahab, AH Rezvani, ED Levin, WA Wilson, HS Swartzwelder, SK Acheson Effects of ethanol, D9-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult rats. Neuroscience Letters, 527:11-15, 2012, PMCID: PMC3477605


Roy NM, B Arpie, J Lugo, E Linney, ED Levin and D Cerutti. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of Embryonic synaptic changes. Neurotoxicology and Teratology, 34:587-591, 2012, PMCID: PMC4338986


Rezvani AH, MC Cauley, EC Johnson, GJ Gatto and ED Levin. Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats. Psychopharmacology, 223:251-258, 2012, PMID:22526540


Larrauri JA and ED Levin. Differential effects of the antidepressant mirtazapine on amphetamine- and dizocilpine-induced PPI deficits. Pharmacology, Biochemistry and Behavior, 102:82-87, 2012, PMID: 22469866


Rezvani, AH, O Timofeeva, D DeCuir, HG Sexton, Y Xiao, CJ Gordon, KJ Kellar and ED Levin. Effects of sazetidine-A, a selective α4β2 nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats. European Journal of Pharmacology, 682:110-117, 2012, PMCID: PMC4065797


Hall FS, A Markou, ED Levin and GR Uhl. Mouse models for studying genetic influences on factors determining smoking cessation success in humans. New York Academy of Sciences,  1248:39-70, 2012, PMCID: PMC4133119


Johnson JE, S Slade, C Wells, A Petro, H Sexton, AH Rezvani, ML Brown, MA Paige, BE McDowell, Y Xiao, KJ Kellar and ED Levin. Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats. Psychopharmacology, 222:269-276, 2012, PMCID: PMC3426624


Levin ED. a7 Nicotinic receptors and cognition. Current Drug Targets, 13:602-606, 2012, PMID: 22300026


Larrauri JA and ED Levin. The α2-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats. Psychopharmacology, 219:99-108 2012, PMID: 21710169


Rezvani AH, AJ Lawrence, MP Arolfo, ED Levin and DH Overstreet. Novel medication targets for the treatment of alcoholism: Preclinical studies. Recent Patents on CNS Drug Discovery, 7:151-162, 2012, PMID: 2574676


Newhouse P, K Kellar, P Aisen, H White, K Wesnes, E Coderre, A Pfaff, H Wilkins, D Howard and ED Levin, Nicotine treatment of mild cognitive impairment: a six-month double-blind pilot clinical trial. Neurology, 78:91-101, 2012, PMCID: PMC3466669


Larrauri JA, MZ Rosenthal, ED Levin, FJ McClernon and NA Schmajuk. Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition. Behavioural Processes, 89:1-7, 2012, PMID: 22001728


Fleming, R.L., Acheson, S.K., Moore, S.D., Wilson, W.A. and Swartzwelder, H.S. In the Rat, Chronic Intermittent Ethanol Exposure During Adolescence Alters the Ethanol Sensitivity of Tonic Inhibition in Adulthood. Alcoholism: Clin. Exp. Res. 36 (2): 279-285, 2012.





Uhl GR, Walther D, Behm FM and Rose, JE.  Menthol preference among smokers: Association with TRPA1 Variants.  Nicotine and Tobacco Research, 13(12): 1311-15, December 2011.  PMID: 21719896;  PMCID: PMC3223576


Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud’homme X and Krystal AD.  Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes.  Biological Psychiatry, 70(8): 794-9,9, Oct 15 2011.  PMID: 21762878


Rose JE.  Nicotine preloading:  the importance of a pre-cessation reduction in smoking behavior.  Psychopharmacology, 217(3): 453-54, October 2011.  DOI: 10.1007/s00213-011-2350-0.  PMID:  21643677


Levin ED, Johnson JE, Slade S, Wells C, Cauley M, Petro A and Rose JE.  Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats.  Journal of Pharmacology and Experimental Therapeutics, 338 (3): 890-896, Sept 2011.  PMID: 21636655; PMCID: PMC3164341


Bevins R, Kenny P and Rose JE.  Response: a quest and a wager.  Addiction Science and Clinical Practice, 6(1): 16-17, July 2011.  PMID: 22003418;  PMCID: PMC3188828


Levin ED, Slade S, Wells C, Petro A and Rose JE.  D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response.  Pharmacology Biochemistry and Behavior, 98 (2): 210-214, Apr 2011. PMID: 21192967; PMCID: PMC3057231


Uhl GR and Rose JE. Individualized smoking cessation treatment: roles for sets of genomic markers.  Personalized Medicine, 8 (2): 119-121, Mar 2011


Levin ED, Slade S, Wells C, Pruitt M, Cousins V, Cauley M, Petro A, Hampton D and Rose JE.  Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.  European Journal of Pharmacology, 650(1): 256-60, Jan 2011. PMID: 20951696


Sledge D, J Yen, T Morton, L Dishaw, A Petro, S Donerly, E Linney and ED Levin. Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicology and Teratology, 33:742-751, 2011, PMCID: PMC3225562


Yen J, S Donerly, ED Levin and E A Linney. Differential acetylcholinesterase inhibition of  chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicology and Teratology, 33:735-741, 2011, PMCID: PMC3225599


Levin, ED, D Sledge, S Roach, A Petro, S Donerly, and E Linney. Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicology and Teratology, 33:668-673, 2011, PMCID: PMC3225500


Levin ED, S Slade, C Wells, M Cauley, A Petro, A Vendittelli, M Johnson, P Williams, K Horton, AH Rezvani. Threshold of adulthood for the onset of nicotine self-administration in male and female rats. Behavioural Brain Research, 225:473-481, 2011, PMCID: PMC3179820


Timofeeva OA and ED Levin. Glutamate and nicotinic receptor interactions in working memory: Importance for the cognitive impairment of schizophrenia. Neuroscience, 195:21-36


Levin ED, PJ Bushnell and AH Rezvani. Attention-modulating effects of cognitive enhancers.  Pharmacology, Biochemistry and Behavior, 99:146-154, 2011, PMCID: PMC3114188


Rezvani AH, M Cauley, H Sexton, Y Xiao, ML Brown, MA Paige, BE McDowell, KJ Kellar, and ED Levin. Sazetidine-A, a selective a4b2 nicotinic acetylcholine receptor ligand: Effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. Psychopharmacology, 215:621-630, 2011, PMID: 21274704.


Schramm-Sapyta NL, MC Cauley, S Glowacz, KA Stepp, ED Levin and CM Kuhn. Role of individual and developmental differences in voluntary cocaine intake in rats. Psychopharmacology, 215:493-504, 2011, PMCID: PMC3187717


Levin ED. Zebrafish assessment of cognitive improvement and anxiolysis: Filling the gap between in vitro and rodent models for drug development. Reviews in the Neurosciences, 22:75-84, 2011, PMCID: PMC4691346.


Cippitelli A, EJ Robinson, L Eisenberg, AH Rezvani, ED. Levin, P Bonaventure, T Motley, TW Lovenberg, M Heilig and A Thorsell. The novel, selective, and brain penetrant NPY Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse and anxiety. Alcohol, 45:567-576, 2011, PMID: 21145691.


Powers CM, ED Levin, FJ Seidler and TA Slotkin. Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. Neurotoxicology and Teratology, 33:329-332, 2011, PMCID: PMC3071894.


Galici R, AH  Rezvani, L Aluisio, B Lord, ED Levin, I Fraser, J Boggs, N Welty, J Shoblock, T Motley, MA Letavic, NI Carruthers, C Dugovic, TW Lovenberg and P Bonaventure. JNJ-39220675, a novel selective histamine H-3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology, 214:829-841, 2011; PMCID: in process.


Fleming, R., Acheson, S., Moore, S., Wilson, W. and Swartzwelder, H.S. GABA Transport Modulates the Ethanol Sensitivity of Tonic Inhibition in the Rat Dentate Gyrus. Alcohol 45(6):577-583, 2011.


Acheson, S.K., Moore, N.L.T., Kuhn, C.M., Wilson, W.A. and Swartzwelder, H.S. The synthetic cannabinoid, WIN 55212-2, differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals. Neuroscience Letters 487(3): 411-414, 2011





Dehkordi O, Rose JE, Balan KV, Millis RM, Bhatti B & Jayam-Trouth A.  Co-expression of nAChRs and molecules of the bitter taste transduction pathway by epithelial cells of intrapulmonary airways.  Life Sciences, 86: 281-288, 2010.  PMID: 20060845


Levin ED, Hampton D and Rose JE.  IV nicotine self-administration in rats using the consummatory operant licking response.  Physiology and Behavior,  101(5): 755-8, Dec 2010. PMID: 20804779


Rose JE, Behm FM, Murugesan T and McClernon FJ. Silver acetate interactions with nicotine and non-nicotine smoke components.  Experimental and Clinical Psychopharmacology, 18 (6): 462-469, Dec 2010.  PMID: 21186921


Uhl GR, Drgon T, Johnson C, Ramoni MF, Behm FM and Rose JE.  Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.  Molecular Medicine,  16 (11-12): 513-526, Nov-Dec 2010.  PMID: 20811658;  PMCID: PMC2972392


Rose JE, Turner JE, Murugesan T, Behm, FM and Laugesen, M.  Pulmonary delivery of nicotine pyruvate: sensory and pharmacokinetic characteristics.  Experimental and Clinical Psychopharmacology, 18 (5): 385-394, Oct 2010.  PMID: 20939642


Rose JE.  Stress alleviation and reward enhancement: Two promising targets for relapse prevention.  Biological Psychiatry, 68 (8):687-688, 2010. PMID: 20888456


Rose JE, Salley A, Behm FM, Bates JE and Westman EC. Reinforcing effects of nicotine and non- nicotine components of cigarette smoke. Psychopharmacology, 210:1–12, 2010.  PMID: 20358364;   PMCID: PMC4154143


Froeliger B, Kozink RV, Rose JE, Behm FM, Salley AN, and McClernon FJ.  Hippocampal and striatal grey matter volume are associated with a smoking cessation treatment outcome: Results of an exploratory voxel-based morphometric analysis. Psychopharmacology, 210(4): 577-583, 2010.  DOI 10.1007/s00213-010-1862-3 PMID: 20424827.


Kozink RV, Lutz AM, Rose JE, Froeliger B, and McClernon FJ.  Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition.  Addiction Biology, 15(4) 480-90, October 2010.  DOI: 10.1111/j.1369-1600.2010.00252.x  PMID: 21040240;  PMCID: PMC2996612


Rezvani AH, Slade S, Wells C, Petro A, Lumeng L, Li T-K, Xiao Y, Brown ML,  Paige MA, McDowell BE, Rose JE, Kellar KJ, and Levin ED.  Effects of sazetidine-a, a selective a4b2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively-bred alcohol preferring (P) rats.  Psychopharmacology, 211: 161-174, 2010. DOI 10.1007/s00213-010-1878-8.  PMID: 20535453;  PMCID: PMC3695635


Rose JE, Behm FM, Drgon T, Johnson C and Uhl GR. Personalized smoking cessation: interactions between nicotine dose, dependence and quit success genotype score. Molecular Medicine, Aug;16(7-8):247-53, 2010. Epub 2010 Mar 17.  PMID: 20379614; PMCID: PMC2896464


Tobacco and Genetics Consortium.  Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 2010 May;42(5):441-7. Epub 2010 Apr 25.  PMID: 20418890;  PMCID: PMC2914600


Rose JE, Mukhin AG, Lokitz SJ, Turkington TG, Herskovic J, Behm FM, Garg S and Garg PK. Kinetics of brain nicotine accumulation in dependent and non-dependent smokers assessed with PET and cigarettes containing 11C-nicotine. Proceedings of the National Academy of Sciences, 107 (11): 5190-5, Mar 2010.  published online March 8, 2010, doi: 10.1073/pnas.0909184107.  PMID: 20212132;  PMCID: PMC2841893


Sanders D, Simkiss D, Braddy D, Baccus S, Morton T, Cannady R, Weaver N, Rose JE and Levin ED. Nicotinic receptors in the habenula: Importance for memory. Neuroscience, 17;166(2):386-90, 2010.  PMID: 20034548


Levin ED, Rezvani AH, Xiao Y, Slade S, Cauley M, Wells C, Hampton D, Petro A, Rose JE, Brown ML, Paige MA, McDowell BE and Kellar K. Sazetidine-A, a selective a4b2 nicotinic receptor desensitizing agent and partial agonist reduces nicotine self-administration in rats. Journal of Pharmacology and Experimental Therapeutics, 332:933–939, 2010.  PMID: 20007754


Larrauri JA and ED Levin. PPI deficit induced by amphetamine is attenuated by the histamine H1 antagonist pyrilamine, but is exacerbated by the serotonin 5HT2 antagonist ketanserin. Psychopharmacology, 212:551-558, 2010, PMID: 20811878


Aschner M, ED Levin, C Suñol, JO Olopade, KJ Helmcke, DS Avila, D Sledge, RH Ali, L Upchurch, S Donerly, E Linney, A Forsby, P Ponnoru and JE Connor. Gene-environment interactions: neurodegeneration in non-mammals and mammals. Neurotoxicology, 31:582-588, 2010, PMCID: PMC2912949.


Rezvani AH, H Sexton and ED Levin. Persistent high alcohol consumption in alcohol- preferring (P) rats results from a lack of normal aversion after forced alcohol exposure. Alcohol and Alcoholism, 45:219-222, 2010, PMCID: PMC2899945


Adigun AA, N Wrench, ED Levin, FJ Seidler and TA Slotkin. Neonatal parathion exposure and interactions with a high-fat diet in adulthood:  Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum. Brain Research Bulletin, 81:605-612, 2010, PMCID: PMC2826615.


Levin ED, OA Timofeeva, L Yang, A Petro, IT Ryde, N Wrench, FJ Seidler and TA Slotkin. Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behavioural Brain Research, 208:319-327, 2010, PMCID: PMC2831164


Lassiter TL, IT Ryde, ED Levin, FJ Seidler and TA Slotkin. Neonatal exposure to parathion alters lipid metabolism in adulthood:  Interactions with dietary fat intake. Brain Research Bulletin, 81:85-91, 2010, PMCID: PMC2795103.


Timofeeva OA, D Eddins, J Yakel, P Blackshear and ED Levin. Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze. Brain Research, 1308:147-152, 2010. PMCID: PMC2806651.


Aschner M, K Crofton and ED Levin. Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology. Neurotoxicology and Teratology, 32:1-3, 2010, PMCID: PMC2818089.


Eddins D, D Cerutti, P Williams, E Linney and ED Levin. Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: Comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicology and Teratology, 32:99-108, 2010, PMCID: PMC2885770.


Timofeeva OA and ED Levin. Lasting behavioral consequences of organophosphate pesticide exposure during development. In: Handbook of Pesticide Toxicology, 3rd Edition, Ed. R. Krieger, Academic Press, New York, p. 837-846, 2010.


Levin ED. Nicotinic receptor systems and neurobehavioral function in zebrafish. In: Zebrafish Models in Neurobehavioral Research, Neuromethods 52, Eds. AV Kalueff and JM Cachat, pp. 89-100, Springer, New York, NY, 2010.


Moore, N.L.T., Greenleaf, A.L.R., Acheson, S.K., Wilson, W.A., Swartzwelder, H.S. and Kuhn, C.M. Role of CB1 desensitization in greater tetrahydroxannabinol impairment of memory in adolescent rats. J. Pharmacol. Exp. Ther. 335(2): 294-301, 2010


Yan, H., Li, Q., Madison, R., Wilson, W.A. and Swartzwelder, H.S. Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats. J. Pharmacol. Exp. Ther.335(1): 51-60, 2010


Rabiner, D.L., Anastopoulos, A.D., Costello, E.J., Hoyle, R.H. and Swartzwelder, H.S. Predictors of Nonmedical ADHD Medication Use by College Students. Journal of Attention Disorders 13(6): 640-8, 2010.


Li, Q., Yan, H., Wilson, W.A. and Swartzwelder, H.S. Modulation of NMDA and AMPAmediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells. Brain Research 1342: 127-137, 2010